Regio- and Diastereochemical Aspects of the Additions of Li or Zn Derivatives of Methoxypropene to Oxazolidines Derived from Phenylglycinol
Résumé
Diastereoselective additions of methoxypropene-derived lithium and zinc reagents to oxazolidines are investigated. The lithium allylic carbanion reacts with oxazolidines to afford mainly the beta-amino alcohols with an enol ether function (gamma-adduct) and the zinc derivative leads to amino alcohols with an allyl ether function (alpha-adduct).