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Chapitre D'ouvrage Année : 2010

Modeling voltage-dependent channels.

Résumé

This chapter describes the voltage-gated ion channels. It considers the different types of formalisms in modeling ionic currents as the action potential and voltage-clamp recordings of the T-type calcium current in thalamic neurons. The chapter specifically reviews the voltage-clamp behavior of the sodium channel and the genesis of action potentials, as well as the characteristics of the T-type calcium current and the genesis of bursts of action potentials by the T-current in thalamic neurons. It shows that nonlinear thermodynamic models offer fits of a quality comparable to empirical Hodgkin-Huxley models, but that their form is physically more plausible.
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Dates et versions

hal-00378023 , version 1 (23-04-2009)

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Alain Destexhe, J.R. Huguenard. Modeling voltage-dependent channels.. Erik De Schutter. Computational Modeling Methods for Neuroscientists, The MIT Press, pp.107-137, 2010, Computational Neuroscience Series, 978-0262013277. ⟨10.7551/mitpress/9780262013277.001.0001⟩. ⟨hal-00378023⟩

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