Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review. - Archive ouverte HAL Access content directly
Journal Articles Journal of Infectious Diseases Year : 2009

Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review.

Abstract

We present a case of disseminated congenital toxoplasmosis in a newborn born to a mother who had been immunized against toxoplasmosis before conception. The mother was reinfected, likely by ingestion of imported raw horse meat during pregnancy. This clinical presentation is exceptional in France and raised the possibility of infection by a highly virulent Toxoplasma strain. The strain responsible was isolated from the peripheral blood of the newborn, and when genotyped with microsatellite markers, it exhibited an atypical genotype, one which is very uncommon in Europe but had been described in South America. We tested the hypothesis of a reinfection with a different genotype by using an experimental mouse model, which confirmed that acquired immunity against European Toxoplasma strains may not protect against reinfection by atypical strains acquired during travel outside Europe or by eating imported meat.

Dates and versions

hal-00374759 , version 1 (09-04-2009)

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Cite

Annie Elbez-Rubinstein, Daniel Ajzenberg, Marie-Laure Dardé, Aurélien Dumètre, Hélène Yera, et al.. Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review.. Journal of Infectious Diseases, 2009, 199 (2), pp.280-5. ⟨10.1086/595793⟩. ⟨hal-00374759⟩
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