Direct repair of a synthetic 5S-configured spore photoproduct by a spore photoproduct lyase. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2006

Direct repair of a synthetic 5S-configured spore photoproduct by a spore photoproduct lyase.

Résumé

The spore photoproduct lyase is a Fe-S/AdoMet DNA repair enzyme, which directly repairs spore lesions, induced by UV irradiation of spores, using an unknown radical mechanism. The air sensitive radical SAM enzyme was for the first time challenged with synthetically pure substrates. It was found that the enzyme recognizes a synthetic 5S-configured spore lesion without the central phosphodiester bond. The 5R-configured lesion is in contrast to current belief not a substrate.
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Dates et versions

hal-00374512 , version 1 (08-04-2009)

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Marcus G. Friedel, Olivier Berteau, Carsten J Pieck, Mohamed Atta, Sandrine Ollagnier-De-Choudens, et al.. Direct repair of a synthetic 5S-configured spore photoproduct by a spore photoproduct lyase.. Chemical Communications, 2006, 445-447, pp.445. ⟨10.1039/b514103f⟩. ⟨hal-00374512⟩
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