<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00374101</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T08:28:51+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">In vivo measurement of human brain elasticity using a light aspiration device</title>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Schiavone</surname>
              </persName>
              <email type="md5">798ad317b4791bb3f5c8ffc3d8a859d6</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">patrick-schiavone</idno>
              <idno type="idhal" notation="numeric">742390</idno>
              <idno type="halauthorid" notation="string">46659-742390</idno>
              <idno type="IDREF">https://www.idref.fr/031703313</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0850-7127</idno>
              <affiliation ref="#struct-616"/>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabrice</forename>
                <surname>Chassat</surname>
              </persName>
              <idno type="halauthorid">119648-0</idno>
              <affiliation ref="#struct-1812"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Boudou</surname>
              </persName>
              <email type="md5">18dda985eceea3ebe38e66ceb06cb2bf</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <ptr type="url" target="https://liphy.univ-grenoble-alpes.fr/fr/microtiss"/>
              <idno type="idhal" notation="string">thomas-boudou</idno>
              <idno type="idhal" notation="numeric">13612</idno>
              <idno type="halauthorid" notation="string">8467-13612</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6821-2937</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=CV5vGu0AAAAJ&amp;hl=fr</idno>
              <idno type="IDREF">https://www.idref.fr/130345296</idno>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuel</forename>
                <surname>Promayon</surname>
              </persName>
              <email type="md5">b155af896c574dae33e0d4b4ef47e7b1</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">emmanuel-promayon</idno>
              <idno type="idhal" notation="numeric">172739</idno>
              <idno type="halauthorid" notation="string">2427-172739</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6872-2014</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8934-6793</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=6ge5uxoAAAAJ</idno>
              <idno type="IDREF">https://www.idref.fr/122021150</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6872-2014</idno>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">F.</forename>
                <surname>Valdivia</surname>
              </persName>
              <idno type="halauthorid">386347-0</idno>
              <affiliation ref="#struct-90890"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yohan</forename>
                <surname>Payan</surname>
              </persName>
              <email type="md5">8780c1597a0a6ebb6c6a14123152f3e5</email>
              <email type="domain">imag.fr</email>
              <idno type="idhal" notation="string">yohan-payan</idno>
              <idno type="idhal" notation="numeric">904</idno>
              <idno type="halauthorid" notation="string">2523903-904</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/E-3993-2013</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6012-4123</idno>
              <idno type="IDREF">https://www.idref.fr/069363978</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/E-3993-2013</idno>
              <affiliation ref="#struct-388249"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Patrick</forename>
                <surname>Schiavone</surname>
              </persName>
              <email type="md5">798ad317b4791bb3f5c8ffc3d8a859d6</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2009-04-07 23:24:05</date>
              <date type="whenModified">2025-09-27 18:33:03</date>
              <date type="whenReleased">2009-04-08 08:44:24</date>
              <date type="whenProduced">2009</date>
              <date type="whenEndEmbargoed">2009-04-07</date>
              <ref type="file" target="https://hal.science/hal-00374101v1/document">
                <date notBefore="2009-04-07"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-00374101v1/file/In_vivo_measurement_of_brain_elasticity_revised.pdf" id="file-374101-1060802">
                <date notBefore="2009-04-07"/>
              </ref>
              <ref type="externalLink" target="http://arxiv.org/pdf/0904.1267"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="109618">
                <persName>
                  <forename>Patrick</forename>
                  <surname>Schiavone</surname>
                </persName>
                <email type="md5">798ad317b4791bb3f5c8ffc3d8a859d6</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00374101</idno>
            <idno type="halUri">https://hal.science/hal-00374101</idno>
            <idno type="halBibtex">schiavone:hal-00374101</idno>
            <idno type="halRefHtml">&lt;i&gt;Medical Image Analysis&lt;/i&gt;, 2009, 13 (4), pp.673-678. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.media.2009.04.001"&gt;&amp;#x27E8;10.1016/j.media.2009.04.001&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Medical Image Analysis, 2009, 13 (4), pp.673-678. &amp;#x27E8;10.1016/j.media.2009.04.001&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-374101-1060802"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="LTM" corresp="FMNT">Laboratoire des technologies de la microélectronique</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-GMCAO" corresp="TIMC-IMAG">GMCAO : Geste Médico-Chirurgicaux Assistés par Ordinateur</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">In vivo measurement of human brain elasticity using a light aspiration device</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Schiavone</surname>
                  </persName>
                  <email type="md5">798ad317b4791bb3f5c8ffc3d8a859d6</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">patrick-schiavone</idno>
                  <idno type="idhal" notation="numeric">742390</idno>
                  <idno type="halauthorid" notation="string">46659-742390</idno>
                  <idno type="IDREF">https://www.idref.fr/031703313</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0850-7127</idno>
                  <affiliation ref="#struct-616"/>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabrice</forename>
                    <surname>Chassat</surname>
                  </persName>
                  <idno type="halauthorid">119648-0</idno>
                  <affiliation ref="#struct-1812"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Boudou</surname>
                  </persName>
                  <email type="md5">18dda985eceea3ebe38e66ceb06cb2bf</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <ptr type="url" target="https://liphy.univ-grenoble-alpes.fr/fr/microtiss"/>
                  <idno type="idhal" notation="string">thomas-boudou</idno>
                  <idno type="idhal" notation="numeric">13612</idno>
                  <idno type="halauthorid" notation="string">8467-13612</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6821-2937</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=CV5vGu0AAAAJ&amp;hl=fr</idno>
                  <idno type="IDREF">https://www.idref.fr/130345296</idno>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuel</forename>
                    <surname>Promayon</surname>
                  </persName>
                  <email type="md5">b155af896c574dae33e0d4b4ef47e7b1</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">emmanuel-promayon</idno>
                  <idno type="idhal" notation="numeric">172739</idno>
                  <idno type="halauthorid" notation="string">2427-172739</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6872-2014</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8934-6793</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=6ge5uxoAAAAJ</idno>
                  <idno type="IDREF">https://www.idref.fr/122021150</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6872-2014</idno>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F.</forename>
                    <surname>Valdivia</surname>
                  </persName>
                  <idno type="halauthorid">386347-0</idno>
                  <affiliation ref="#struct-90890"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yohan</forename>
                    <surname>Payan</surname>
                  </persName>
                  <email type="md5">8780c1597a0a6ebb6c6a14123152f3e5</email>
                  <email type="domain">imag.fr</email>
                  <idno type="idhal" notation="string">yohan-payan</idno>
                  <idno type="idhal" notation="numeric">904</idno>
                  <idno type="halauthorid" notation="string">2523903-904</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/E-3993-2013</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6012-4123</idno>
                  <idno type="IDREF">https://www.idref.fr/069363978</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/E-3993-2013</idno>
                  <affiliation ref="#struct-388249"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">16987</idno>
                <idno type="issn">1361-8415</idno>
                <idno type="eissn">1361-8423</idno>
                <title level="j">Medical Image Analysis</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">13</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">673-678</biblScope>
                  <date type="datePub">2009</date>
                </imprint>
              </monogr>
              <idno type="arxiv">0904.1267</idno>
              <idno type="doi">10.1016/j.media.2009.04.001</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Brain shift</term>
                <term xml:lang="en">elastic properties</term>
                <term xml:lang="en">soft tissue characterization</term>
                <term xml:lang="en">inverse finite element</term>
                <term xml:lang="en">aspiration</term>
                <term xml:lang="en">pipette</term>
              </keywords>
              <classCode scheme="halDomain" n="spi.meca.biom">Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]</classCode>
              <classCode scheme="halDomain" n="phys.meca.biom">Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The brain deformation that occurs during neurosurgery is a serious issue impacting the patient "safety" as well as the invasiveness of the brain surgery. Model-driven compensation is a realistic and efficient solution to solve this problem. However, a vital issue is the lack of reliable and easily obtainable patient-specific mechanical characteristics of the brain which, according to clinicians' experience, can vary considerably. We designed an aspiration device that is able to meet the very rigorous sterilization and handling process imposed during surgery, and especially neurosurgery. The device, which has no electronic component, is simple, light and can be considered as an ancillary instrument. The deformation of the aspirated tissue is imaged via a mirror using an external camera. This paper describes the experimental setup as well as its use during a specific neurosurgery. The experimental data was used to calibrate a continuous model. We show that we were able to extract an in vivo constitutive law of the brain elasticity: thus for the first time, measurements are carried out per-operatively on the patient, just before the resection of the brain parenchyma. This paper discloses the results of a difficult experiment and provide for the first time in-vivo data on human brain elasticity. The results point out the softness as well as the highly non-linear behavior of the brain tissue.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-616" status="OLD">
          <idno type="IdRef">184687586</idno>
          <idno type="ISNI">0000 0004 0382 8743</idno>
          <idno type="RNSR">200111811N</idno>
          <idno type="ROR">https://ror.org/036zswm25</idno>
          <orgName>Laboratoire des technologies de la microélectronique</orgName>
          <orgName type="acronym">LTM</orgName>
          <date type="start">1999-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>LETI/DTS 17 rue des martyrs 38054 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ltmlab.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-300016" type="direct"/>
            <relation name="UMR5129 / EP2073" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1812" status="VALID">
          <idno type="IdRef">164068007</idno>
          <idno type="ISNI">0000000122040669</idno>
          <idno type="RNSR">200419758N</idno>
          <idno type="ROR">https://ror.org/00wz2vk41</idno>
          <orgName>Centre de modélisation mathématique / Centro de Modelamiento Matemático [Santiago]</orgName>
          <orgName type="acronym">CMM</orgName>
          <date type="start">2000-01-01</date>
          <desc>
            <address>
              <addrLine>Av. Blanco Encalada 2120, Piso 7 2120 SANTIAGO DE CHILE</addrLine>
              <country key="CL"/>
            </address>
            <ref type="url">http://www.cmm.uchile.cl</ref>
          </desc>
          <listRelation>
            <relation active="#struct-142796" type="direct"/>
            <relation name="IRL2807 / UMI2807 / UMR2071" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-90890" status="INCOMING">
          <orgName>Instituto de NeuroCirugía Asenjo</orgName>
          <desc>
            <address>
              <addrLine>PO Box 3517 Santiago</addrLine>
              <country key="CL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-322552" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388249" status="OLD">
          <orgName>Gestes Medico-chirurgicaux Assistés par Ordinateur</orgName>
          <orgName type="acronym">TIMC-IMAG-GMCAO</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/gmcao</ref>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-142796" status="VALID">
          <idno type="ROR">https://ror.org/047gc3g35</idno>
          <orgName>Universidad de Chile = University of Chile [Santiago]</orgName>
          <orgName type="acronym">UCHILE</orgName>
          <desc>
            <address>
              <addrLine>Av. Libertador Bernardo O'Higgins 1058, Santiago de Chile</addrLine>
              <country key="CL"/>
            </address>
            <ref type="url">http://www.uchile.cl/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-322552" status="INCOMING">
          <orgName>Instituto de NeuroCirugía Asenjo</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>