Transannular Rearrangement of Activated Lactams: Stereoselective Synthesis of Substituted Pyrrolidine-2,4-diones from Diketopiperazines
Résumé
We describe herein the unprecedented reactivity of N-carboxy derivatives of 2,5-diketopiperazines (DKPs). The reaction of these derivatives under basic conditions led to novel substituted pyrrolidine-2,4-diones (1).