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Journal Articles Synthesis: Journal of Synthetic Organic Chemistry Year : 2008

Synthesis of 4-Maleimidobutyric Acid and Related Maleimides

Abstract

Maleimidoalkanoic acids and their activated derivatives, such as their N-hydroxysuccinimide esters, are important, though expensive, linkers for the conjugation of biomolecules. During our synthesis of UCS1025A, we have developed a chromatography-free preparation of 4-maleimidobutyric acid on a one-mole scale.
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hal-00356238 , version 1 (27-01-2009)

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Renata Marcia de Figueiredo, Philipp Oczipka, Roland Fröhlich, Matthias Christmann. Synthesis of 4-Maleimidobutyric Acid and Related Maleimides. Synthesis: Journal of Synthetic Organic Chemistry, 2008, 8, pp.1316-1318. ⟨10.1055/s-2008-1032016⟩. ⟨hal-00356238⟩
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