Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neuron Année : 2003

Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin.

Résumé

Cognitive theories of numerical representation suggest that understanding of numerical quantities is driven by a magnitude representation associated with the intraparietal sulcus and possibly under genetic control. The aim of this study was to investigate, using fMRI and structural imaging, the interaction between the abnormal development of numerical representation in an X-linked condition, Turner syndrome (TS), and the development of the intraparietal sulcus. fMRI during exact and approximate calculation in TS showed an abnormal modulation of intraparietal activations as a function of number size. Morphological analysis revealed an abnormal length, depth, and sulcal geometry of the right intraparietal sulcus, suggesting an important disorganization of this region in TS. Thus, a genetic form of developmental dyscalculia can be related to both functional and structural anomalies of the right intraparietal sulcus, suggesting a crucial role of this region in the development of arithmetic abilities.

Domaines

Imagerie

Dates et versions

hal-00349694 , version 1 (03-01-2009)

Identifiants

Citer

Nicolas Molko, Arnaud Cachia, Denis Rivière, Jean-François Mangin, Marie Bruandet, et al.. Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin.. Neuron, 2003, 40 (4), pp.847-58. ⟨10.1007/s00106-008-1787-x⟩. ⟨hal-00349694⟩
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