VE-cadherin and claudin-5: it takes two to tango.
Résumé
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.
Domaines
Interactions cellulaires [q-bio.CB]
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hal-00340308_edited.pdf (778.86 Ko)
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NCB-final.pdf (342.19 Ko)
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Origine | Fichiers produits par l'(les) auteur(s) |
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Origine | Fichiers produits par l'(les) auteur(s) |
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