The Seine, Yonne and Somme are the main rivers draining northwestern France and flowing into the Channel. During Pleistocene cold stages they were tributaries of the “Fleuve Manche”. They are characterised by well-developed stepped terrace systems showing up to 10 incision steps for the last 1 Ma. After 15 years of research and the synthesis of stratigraphical, sedimentological, bioclimatical data and numerical dating, these terrace systems are interpreted as the response of the fluvial environments to climatic cyclicity, superimposed on a background of slow tectonic uplift. The comparison of these three terrace systems shows that the incision budget is similar within the studied area (about 55–65 m/1 Ma), implying relative homogeneity of uplift. In the main part of the area, beyond marine influence, the analysis of each stepped alluvial formation shows regular sediment balance generally composed of coarse periglacial gravels (pleniglacial), covered by fine-grained sediments locally overlain by calcareous tufa (interglacial). However, in the Lower Seine valley, close to the present coast, the low terrace includes two estuarine interglacial units interbedded within periglacial gravel units. Nevertheless, until recently evidence of full interglacial conditions remained elusive in fluvial contexts, especially in the Somme. To address these issues a new research programme has been launched on tufa deposits that are the best candidate to register the climatic optimum. Initial results from la Celle (Seine), Saint-Acheul and Caours (Somme) allow palaeoenvironmental reconstructions of MIS 11 and 5e, and thus confirm the importance of calcareous tufa to define a reference record of Pleistocene Interglacials for northern France. Moreover, it has been previously demonstrated that the main incision leading to terrace formation can be attributed to the transition between interglacial and glacial (during early glacial phases). The new results from interglacial records have important implications concerning the precise occurrence of the major incision phases within the climatic cycle as they provide the starting point immediately preceding downcutting.