A Direct and Versatile Access to a,a-Disubstituted 2-Pyrrolidinyl-methanols by SmI2-Mediated Reductive Coupling
Résumé
Various a,a-disubstituted 2-pyrrolidinyl-methanols are efficiently prepared in a single step from ketones using a SmI2-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-a,a-diphenylprolinol is also easily prepared and resolved.