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Article Dans Une Revue Oncogene Année : 2005

Caspase-8 sumoylation is associated with nuclear localization.

Résumé

The cysteine protease caspase-8 plays a pivotal role in the initiation of different apoptotic pathways and controls the maturation and differentiation of various cell types including neurons, fibroblasts and lymphocytes. Specific substrates of caspase-8 are present in both the cytoplasm and the nucleus, which may determine the ultimate biological effect of caspase-8. However, the mechanisms regulating the cellular localization of caspase-8 are still unknown. We show here that, in contrast to other caspases such as caspase-9 and -3, caspase-8 can be sumoylated at lysine 156. This sumoylation (i) is associated with the nuclear localization of caspase-8 and (ii) did not impair caspase-8 activation.
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hal-00320527 , version 1 (11-09-2008)

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Laurence Besnault-Mascard, Corinne Leprince, Marie Thérèse Auffredou, Brigitte Meunier, Marie Françoise Bourgeade, et al.. Caspase-8 sumoylation is associated with nuclear localization.. Oncogene, 2005, 24 (20), pp.3268-73. ⟨10.1038/sj.onc.1208448⟩. ⟨hal-00320527⟩
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