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            <title xml:lang="en">NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22.</title>
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                <forename type="first">Antoine</forename>
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            <idno type="halRefHtml">&lt;i&gt;Genes, Chromosomes &amp; Cancer&lt;/i&gt;, 2008, 47 (11), pp.971-7. &lt;a target="_blank" href="https://dx.doi.org/10.1002/gcc.20602"&gt;&amp;#x27E8;10.1002/gcc.20602&amp;#x27E9;&lt;/a&gt;</idno>
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                <title xml:lang="en">NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22.</title>
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                    <forename type="first">Antoine</forename>
                    <surname>Italiano</surname>
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                    <forename type="first">Nathalie</forename>
                    <surname>Ebran</surname>
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                  <idno type="halauthorid">351369-0</idno>
                  <affiliation ref="#struct-73581"/>
                  <affiliation ref="#struct-922"/>
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                    <forename type="first">Rita</forename>
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                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Chevallier</surname>
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                    <forename type="first">Isabelle</forename>
                    <surname>Monticelli</surname>
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                  <idno type="halauthorid">351371-0</idno>
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                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Mainguené</surname>
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                  <idno type="halauthorid">351372-0</idno>
                  <affiliation ref="#struct-73582"/>
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                    <forename type="first">Daniel</forename>
                    <surname>Benchimol</surname>
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                  <idno type="halauthorid">351373-0</idno>
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                    <forename type="first">Florence</forename>
                    <surname>Pedeutour</surname>
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                <title level="j">Genes, Chromosomes &amp; Cancer</title>
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                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">47</biblScope>
                  <biblScope unit="issue">11</biblScope>
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                  <date type="datePub">2008-11</date>
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              <p>Lipomas are frequently characterized by rearrangements resulting in the fusion of the HMGA2 gene (12q14.3) with a variety of partners. Chromosome band 9p22 rearrangements occur in about 1% of lipomas. We report here the molecular cytogenetic analysis of five cases of lipoma with a 9p22 aberration, including the first cytogenetic analysis of a colonic lipoma. Three out of the five cases showed a rearrangement of NFIB at 9p22.3. The NFIB rearrangement involved a fusion with HMGA2 in two cases. We have identified an in-frame fusion of the first three exons of HMGA2 with exon 6 of MSRB3 (12q14.3) and exons 8 and 9 of NFIB by using 3'RACE-PCR in a case of superficial lipoma. In a case of retroperitoneal lipoma we found a fusion of HMGA2 with NFIB by fluorescence in situ hybridization analysis. The colonic lipoma was characterized by a t(9;16;19)(p22;q21;q13) with a rearrangement of NFIB and no rearrangement of HMGA2. NFIB belongs to the nuclear factor I transcription family. It has been previously shown to be fused with HMGA2 in one case of lipoma and to be a recurrent partner of HMGA2 in pleormorphic adenoma of salivary glands. We here demonstrate that NFIB can also be rearranged independently from HMGA2, indicating a potentially important role in lipoma pathobiology. Our findings suggest that the rearrangement of NFIB might be associated with deep-seated lipomas, such as retroperitoneal or gastro-intestinal lipomas. (c) 2008 Wiley-Liss, Inc.</p>
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