Article Dans Une Revue Biochimie Année : 2008

Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells.

Résumé

Pleiotrophin (PTN) is a polypeptide that belongs to a family of heparin-binding growth factor, which displays mitogenic activity for a wide variety of cells. Since PTN induces the proliferation of immune cells the mechanism of action was investigated. In the present study, we show for the first time that PTN induces the expression of inflammatory cytokines including TNF-alpha, IL-1beta and IL-6 in quiescent human peripheral blood mononuclear cells (PBMC). These results emphasize the importance of PTN in the regulation of inflammatory processes. Elucidation of the mechanisms by which a host factor such PTN regulates cytokines production will significantly advance our understanding of endothelium-immunity interactions.

Dates et versions

hal-00319805 , version 1 (09-09-2008)

Identifiants

Citer

Ammar Achour, Jean Pierre M'Bika, Françoise Baudouin, Danièle Caruelle, José Courty. Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells.. Biochimie, 2008, epub ahead of print. ⟨10.1016/j.biochi.2008.04.010⟩. ⟨hal-00319805⟩
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