Article Dans Une Revue European Journal of Control Année : 2008

Identification of Pharmacokinetics Models in the presence of Timing Noise

Résumé

The problem addressed in this paper deals with the parameter estimation of in vitro uptake kinetics of drugs into living cells in presence of timing noise. Effects of the timing noise on the bias and variance of the output error are explicitly determined. A bounded-error parameter estimation approach is proposed as a suited solution to handle this problem. Application results are presented which emphasize the effectiveness of the methodology in such an experimental framework.

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hal-00315413 , version 1 (28-08-2008)

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Thierry Bastogne, Sophie Mézières-Wantz, Nacim Ramdani, Pierre Vallois, Muriel Barberi-Heyob. Identification of Pharmacokinetics Models in the presence of Timing Noise. European Journal of Control, 2008, 14 (2), pp.149-157. ⟨10.3166/EJC.14.1-9⟩. ⟨hal-00315413⟩
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