A new G(gamma) chain variant: Hb F-Bron [gamma20(B2)val-->Ala]. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Hemoglobin Année : 2005

A new G(gamma) chain variant: Hb F-Bron [gamma20(B2)val-->Ala].

Résumé

A new G(gamma) hemoglobin (Hb) variant, Hb F-Bron [gamma20(B2)Val-->Ala] on the first exon of the G(gamma)-globin gene is described. The variant was characterized by DNA sequencing and mass spectrometry (MS). Hematological abnormalities included hypochromia and microcytosis and were probably caused by an interaction with an alpha-thalassemia (thal) (3.7 kb) deletion in the heterozygous state.A new G(gamma) hemoglobin (Hb) variant, Hb F-Bron [gamma20(B2)Val-->Ala] on the first exon of the G(gamma)-globin gene is described. The variant was characterized by DNA sequencing and mass spectrometry (MS). Hematological abnormalities included hypochromia and microcytosis and were probably caused by an interaction with an alpha-thalassemia (thal) (3.7 kb) deletion in the heterozygous state.
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Dates et versions

hal-00314096 , version 1 (27-08-2008)

Identifiants

  • HAL Id : hal-00314096 , version 1
  • PUBMED : 16370494

Citer

P. Lacan, N. Burnichon, M. Becchi, I. Zanella-Cleon, Marc Aubry, et al.. A new G(gamma) chain variant: Hb F-Bron [gamma20(B2)val-->Ala].. Hemoglobin, 2005, 29, pp.301-305. ⟨hal-00314096⟩
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