<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00306455</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-04-29T09:51:20+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis.</title>
            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Elabd</surname>
              </persName>
              <idno type="halauthorid">335701-0</idno>
              <affiliation ref="#struct-922"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Armelle</forename>
                <surname>Basillais</surname>
              </persName>
              <idno type="halauthorid">335702-0</idno>
              <affiliation ref="#struct-397375"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Beaupied</surname>
              </persName>
              <idno type="halauthorid">335703-0</idno>
              <affiliation ref="#struct-397375"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">V?onique</forename>
                <surname>Breuil</surname>
              </persName>
              <idno type="halauthorid">335704-0</idno>
              <affiliation ref="#struct-23080"/>
              <affiliation ref="#struct-69123"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicole</forename>
                <surname>Wagner</surname>
              </persName>
              <email type="md5">64950e29128dcd45bcc512ddea27f682</email>
              <email type="domain">unice.fr</email>
              <idno type="idhal" notation="numeric">758919</idno>
              <idno type="halauthorid" notation="string">240629-758919</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2746-0707</idno>
              <idno type="IDREF">https://www.idref.fr/188792082</idno>
              <affiliation ref="#struct-1060434"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marcel</forename>
                <surname>Scheideler</surname>
              </persName>
              <idno type="halauthorid">335705-0</idno>
              <affiliation ref="#struct-65509"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laure Emmanuelle</forename>
                <surname>Zaragosi</surname>
              </persName>
              <email type="md5">c8d33766e02c5a8e0ae957b20040eb1f</email>
              <email type="domain">ipmc.cnrs.fr</email>
              <idno type="idhal" notation="numeric">803387</idno>
              <idno type="halauthorid" notation="string">335706-803387</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6747-7928</idno>
              <idno type="IDREF">https://www.idref.fr/11900920X</idno>
              <affiliation ref="#struct-922"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Massiéra</surname>
              </persName>
              <idno type="halauthorid">335707-0</idno>
              <affiliation ref="#struct-922"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuel</forename>
                <surname>Lemichez</surname>
              </persName>
              <idno type="halauthorid">136222-0</idno>
              <affiliation ref="#struct-2985"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Zlatko</forename>
                <surname>Trajanoski</surname>
              </persName>
              <idno type="halauthorid">335708-0</idno>
              <affiliation ref="#struct-414971"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Georges</forename>
                <forename type="middle">F.</forename>
                <surname>Carle</surname>
              </persName>
              <email type="md5">5856879e4735329b87c1ecc55d87376d</email>
              <email type="domain">unice.fr</email>
              <idno type="idhal" notation="numeric">845484</idno>
              <idno type="halauthorid" notation="string">175845-845484</idno>
              <idno type="IDREF">https://www.idref.fr/112126154</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3901-1052</idno>
              <idno type="VIAF">https://viaf.org/viaf/202178799</idno>
              <affiliation ref="#struct-69123"/>
              <affiliation ref="#struct-1764"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Liana</forename>
                <surname>Euller-Ziegler</surname>
              </persName>
              <idno type="halauthorid">266108-0</idno>
              <affiliation ref="#struct-23080"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gérard</forename>
                <surname>Ailhaud</surname>
              </persName>
              <idno type="halauthorid">335709-0</idno>
              <affiliation ref="#struct-922"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claude-Laurent</forename>
                <surname>Benhamou</surname>
              </persName>
              <email type="md5">7e801c612966fab5cfe6051d192bd6d4</email>
              <email type="domain">chr-orleans.fr</email>
              <idno type="idhal" notation="numeric">834753</idno>
              <idno type="halauthorid" notation="string">159767-834753</idno>
              <affiliation ref="#struct-3016"/>
              <affiliation ref="#struct-300639"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Dani</surname>
              </persName>
              <idno type="idhal" notation="numeric">758000</idno>
              <idno type="halauthorid" notation="string">206642-758000</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3228-0230</idno>
              <affiliation ref="#struct-922"/>
              <affiliation ref="#struct-2882"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ez Zoubir</forename>
                <surname>Amri</surname>
              </persName>
              <email type="md5">556e199f38ea5400ea54be3c387f3431</email>
              <email type="domain">unice.fr</email>
              <idno type="idhal" notation="string">ez-zoubir-amri</idno>
              <idno type="idhal" notation="numeric">15820</idno>
              <idno type="halauthorid" notation="string">335710-15820</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8426-5396</idno>
              <idno type="IDREF">https://www.idref.fr/077154959</idno>
              <affiliation ref="#struct-922"/>
              <affiliation ref="#struct-880"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Georges</forename>
                <surname>Carle</surname>
              </persName>
              <email type="md5">9e4047f211b45e53f66c71c768dd9015</email>
              <email type="domain">univ-cotedazur.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2008-07-25 17:24:20</date>
              <date type="whenModified">2026-04-29 09:50:02</date>
              <date type="whenReleased">2008-07-25 17:24:20</date>
              <date type="whenProduced">2008-06-26</date>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113415">
                <persName>
                  <forename>Georges</forename>
                  <surname>Carle</surname>
                </persName>
                <email type="md5">9e4047f211b45e53f66c71c768dd9015</email>
                <email type="domain">univ-cotedazur.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00306455</idno>
            <idno type="halUri">https://hal.science/hal-00306455</idno>
            <idno type="halBibtex">elabd:hal-00306455</idno>
            <idno type="halRefHtml">&lt;i&gt;Stem Cells / Stem Cells (Miamisburg)&lt;/i&gt;, 2008, 26 (9), epub ahead of print. &lt;a target="_blank" href="https://dx.doi.org/10.1634/stemcells.2008-0127"&gt;&amp;#x27E8;10.1634/stemcells.2008-0127&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Stem Cells / Stem Cells (Miamisburg), 2008, 26 (9), epub ahead of print. &amp;#x27E8;10.1634/stemcells.2008-0127&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UNICE">Université Nice Sophia Antipolis</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="UNIV-ORLEANS">Université d'Orléans</idno>
            <idno type="stamp" n="URCA">Publications de l'Université de Reims Champagne-Ardenne</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="UNIV-COTEDAZUR">Université Côte d'Azur</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="IBDM">IBDM - Institut de Biologie du Développement de Marseille</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="TEST-NICE">test nice</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Elabd</surname>
                  </persName>
                  <idno type="halauthorid">335701-0</idno>
                  <affiliation ref="#struct-922"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Armelle</forename>
                    <surname>Basillais</surname>
                  </persName>
                  <idno type="halauthorid">335702-0</idno>
                  <affiliation ref="#struct-397375"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Beaupied</surname>
                  </persName>
                  <idno type="halauthorid">335703-0</idno>
                  <affiliation ref="#struct-397375"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">V?onique</forename>
                    <surname>Breuil</surname>
                  </persName>
                  <idno type="halauthorid">335704-0</idno>
                  <affiliation ref="#struct-23080"/>
                  <affiliation ref="#struct-69123"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicole</forename>
                    <surname>Wagner</surname>
                  </persName>
                  <email type="md5">64950e29128dcd45bcc512ddea27f682</email>
                  <email type="domain">unice.fr</email>
                  <idno type="idhal" notation="numeric">758919</idno>
                  <idno type="halauthorid" notation="string">240629-758919</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2746-0707</idno>
                  <idno type="IDREF">https://www.idref.fr/188792082</idno>
                  <affiliation ref="#struct-1060434"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marcel</forename>
                    <surname>Scheideler</surname>
                  </persName>
                  <idno type="halauthorid">335705-0</idno>
                  <affiliation ref="#struct-65509"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laure Emmanuelle</forename>
                    <surname>Zaragosi</surname>
                  </persName>
                  <email type="md5">c8d33766e02c5a8e0ae957b20040eb1f</email>
                  <email type="domain">ipmc.cnrs.fr</email>
                  <idno type="idhal" notation="numeric">803387</idno>
                  <idno type="halauthorid" notation="string">335706-803387</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6747-7928</idno>
                  <idno type="IDREF">https://www.idref.fr/11900920X</idno>
                  <affiliation ref="#struct-922"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Massiéra</surname>
                  </persName>
                  <idno type="halauthorid">335707-0</idno>
                  <affiliation ref="#struct-922"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuel</forename>
                    <surname>Lemichez</surname>
                  </persName>
                  <idno type="halauthorid">136222-0</idno>
                  <affiliation ref="#struct-2985"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Zlatko</forename>
                    <surname>Trajanoski</surname>
                  </persName>
                  <idno type="halauthorid">335708-0</idno>
                  <affiliation ref="#struct-414971"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Georges</forename>
                    <forename type="middle">F.</forename>
                    <surname>Carle</surname>
                  </persName>
                  <email type="md5">5856879e4735329b87c1ecc55d87376d</email>
                  <email type="domain">unice.fr</email>
                  <idno type="idhal" notation="numeric">845484</idno>
                  <idno type="halauthorid" notation="string">175845-845484</idno>
                  <idno type="IDREF">https://www.idref.fr/112126154</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3901-1052</idno>
                  <idno type="VIAF">https://viaf.org/viaf/202178799</idno>
                  <affiliation ref="#struct-69123"/>
                  <affiliation ref="#struct-1764"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Liana</forename>
                    <surname>Euller-Ziegler</surname>
                  </persName>
                  <idno type="halauthorid">266108-0</idno>
                  <affiliation ref="#struct-23080"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gérard</forename>
                    <surname>Ailhaud</surname>
                  </persName>
                  <idno type="halauthorid">335709-0</idno>
                  <affiliation ref="#struct-922"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claude-Laurent</forename>
                    <surname>Benhamou</surname>
                  </persName>
                  <email type="md5">7e801c612966fab5cfe6051d192bd6d4</email>
                  <email type="domain">chr-orleans.fr</email>
                  <idno type="idhal" notation="numeric">834753</idno>
                  <idno type="halauthorid" notation="string">159767-834753</idno>
                  <affiliation ref="#struct-3016"/>
                  <affiliation ref="#struct-300639"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Dani</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">758000</idno>
                  <idno type="halauthorid" notation="string">206642-758000</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3228-0230</idno>
                  <affiliation ref="#struct-922"/>
                  <affiliation ref="#struct-2882"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ez Zoubir</forename>
                    <surname>Amri</surname>
                  </persName>
                  <email type="md5">556e199f38ea5400ea54be3c387f3431</email>
                  <email type="domain">unice.fr</email>
                  <idno type="idhal" notation="string">ez-zoubir-amri</idno>
                  <idno type="idhal" notation="numeric">15820</idno>
                  <idno type="halauthorid" notation="string">335710-15820</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8426-5396</idno>
                  <idno type="IDREF">https://www.idref.fr/077154959</idno>
                  <affiliation ref="#struct-922"/>
                  <affiliation ref="#struct-880"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">19152</idno>
                <idno type="issn">1066-6099</idno>
                <idno type="eissn">1549-4918</idno>
                <title level="j">Stem Cells / Stem Cells (Miamisburg)</title>
                <imprint>
                  <publisher>Alphamed Press</publisher>
                  <biblScope unit="volume">26</biblScope>
                  <biblScope unit="issue">9</biblScope>
                  <biblScope unit="pp">epub ahead of print</biblScope>
                  <date type="datePub">2008-06-26</date>
                  <date type="dateEpub">2008-06-26</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1634/stemcells.2008-0127</idno>
              <idno type="prodinra">250619</idno>
              <idno type="pubmed">18583541</idno>
              <idno type="wos">000259364800021</idno>
              <ref target="http://hal.archives-ouvertes.fr/hal-00306455" type="seeAlso"/>
              <ref target="http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&amp;term=18583541" type="seeAlso"/>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Osteoporosis constitutes a major worldwide public health burden characterized by enhanced skeletal fragility. Bone metabolism is the combination of bone resorption by osteoclasts and bone formation by osteoblasts. While increase in bone resorption is considered as the main contributor of bone loss that may lead to osteoporosis, this loss is accompanied by increased bone marrow adiposity. Osteoblasts and adipocytes share the same precursor cell and an inverse relationship exists between the two lineages. Therefore, identifying signaling pathways that stimulates mesenchymal stem cells osteogenesis at the expense of adipogenesis is of major importance in order to develop new therapeutic treatments. For this purpose, we identified by transcriptomic analysis the oxytocin receptor pathway as a potential regulator of the osteoblast/adipocyte balance of human multipotent adipose-derived stem (hMADS) cells. Both oxytocin (OT) and carbetocin (Cb, a stable OT analogue) negatively modulate adipogenesis while promoting osteogenesis in both hMADS cells and human bone marrow mesenchymal stromal cells (hBMSC). Consistent with these observations ovariectomized (OVX) mice and rats, which become osteoporotic and exhibit disequilibrium of this balance, have significant decreased OT levels compared to sham-operated controls. Subcutaneous OT injection reverses bone loss in OVX mice and reduces marrow adiposity. Clinically, plasma OT levels are significantly lower in postmenopausal women developing osteoporosis than in their healthy counterparts. Taken together, these results suggest that plasma OT levels represent a novel diagnostic marker for osteoporosis and that OT administration holds promise as a potential therapy for this disease. ______________________________________________________________________________ Author contributions: C.E.: carried out most of the experiments, data analysis and interpretation, collection and assembly of data; A.B., H.B. and C.B.: analysis of bone micro-architecture and biomechanical parameters of mice, manuscript writing; L.Z., M.S. and Z.T.: microarray analysis, data analysis and interpretation; F.M.: contribution to the mice study, data analysis and interpretation; V.B., G.F.C. and L.E.: provision of patients, data analysis and interpretation; N.W.: histological analysis of mice tissues, data analysis and interpretation; E.L.: provision of study material, data analysis and interpretation; C.D.: data analysis and interpretation, manuscript writing; G.A.: conception and design, data analysis and interpretation, manuscript writing; E.A.: conception and design, collection and assembly of data, data analysis and interpretation, manuscript writing.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-922" status="OLD">
          <orgName>Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer</orgName>
          <orgName type="acronym">IBDC</orgName>
          <desc>
            <address>
              <addrLine>Centre Antoine lacassagne 33 Avenue de volombrose 06189 NICE CEDEX 2</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation name="UMR6543" active="#struct-441569" type="direct"/>
            <relation active="#struct-1039632" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-397375" status="INCOMING">
          <orgName>INSERM U658</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-3016" type="direct"/>
            <relation name="U658" active="#struct-300297" type="indirect"/>
            <relation name="U658" active="#struct-300639" type="indirect"/>
            <relation name="U658" active="#struct-303623" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-23080" status="VALID">
          <orgName>Service de rhumatologie</orgName>
          <desc>
            <address>
              <addrLine>Route St Antoine de Ginestière, 06200 Nice Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300113" type="direct"/>
            <relation active="#struct-300155" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-69123" status="VALID">
          <orgName>Génétique, physiopathologie et ingénierie du tissu osseux</orgName>
          <orgName type="acronym">GéPITOS</orgName>
          <desc>
            <address>
              <addrLine>Avenue de Valombrose 06107 NICE CEDEX 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www-gpm.unice.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation name="UMR6235" active="#struct-441569" type="direct"/>
            <relation active="#struct-1039632" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1060434" status="OLD">
          <orgName>Institut de Biologie du Développement de Marseille</orgName>
          <orgName type="acronym">IBDM</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Case 907 - Parc Scientifique de Luminy 13288 Marseille Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ibdm.univ-mrs.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-198056" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-65509" status="VALID">
          <idno type="ROR">https://ror.org/00d7xrm67</idno>
          <orgName>Graz University of Technology [Graz]</orgName>
          <orgName type="acronym">TU Graz</orgName>
          <desc>
            <address>
              <addrLine>Rechbauerstr. 12,  8010 Graz</addrLine>
              <country key="AT"/>
            </address>
            <ref type="url">https://www.tugraz.at/en/home/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-2985" status="VALID">
          <orgName>Toxines bactériennes dans la relation hôtes-pathogènes</orgName>
          <desc>
            <address>
              <addrLine>Faculte de Medecine 28, Avenue de Valombrose 06107 NICE CEDEX 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unice.fr/inserm-toxin-bacteria</ref>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation active="#struct-300622" type="direct"/>
            <relation name="U627" active="#struct-303623" type="direct"/>
            <relation active="#struct-1039632" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-414971" status="INCOMING">
          <orgName>U907</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1764" status="OLD">
          <orgName>Génétique et signalisation moléculaire</orgName>
          <orgName type="acronym">GSM</orgName>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Pasteur Avenue de Valombrose 06107 Nice Cedex 2</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-117617" type="direct"/>
            <relation active="#struct-300016" type="direct"/>
            <relation active="#struct-300113" type="direct"/>
            <relation name="IFR50" active="#struct-303623" type="direct"/>
            <relation name="IFR50" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-3016" status="OLD">
          <idno type="IdRef">167384589</idno>
          <idno type="RNSR">200616348Y</idno>
          <orgName>Caractérisation du tissu osseux par imagerie : techniques et applications</orgName>
          <date type="start">2006-01-01</date>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <addrLine>CHR Orléans 1, Rue Porte Madeleine 45032 Orléans Cedex 1</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="U658" active="#struct-300297" type="direct"/>
            <relation name="U658" active="#struct-300639" type="direct"/>
            <relation name="U658" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300639" status="VALID">
          <idno type="IdRef">02661457X</idno>
          <orgName>Centre Hospitalier Régional d'Orléans</orgName>
          <orgName type="acronym">CHRO</orgName>
          <date type="start">2015-01-01</date>
          <date type="end">2023-10-11</date>
          <desc>
            <address>
              <addrLine>14 Avenue de l'Hôpital, 45100 Orléans</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chr-orleans.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-2882" status="OLD">
          <orgName>Dynamique cellulaire et moléculaire de la muqueuse respiratoire</orgName>
          <desc>
            <address>
              <addrLine>Hopital Maison Blanche 45, Rue Cognacq Jay 51092 Reims Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-reims.fr/Labos/INSERM514/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7569" type="direct"/>
            <relation active="#struct-300611" type="direct"/>
            <relation name="U514" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-880" status="OLD">
          <orgName>Interactions plantes-microorganismes et santé végétale</orgName>
          <orgName type="acronym">IPMSV</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>123, Boulevard Francis Meillant - BP 2078 06606 ANTIBES CEDEX</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR1064" active="#struct-92114" type="direct"/>
            <relation active="#struct-117617" type="direct"/>
            <relation name="UMR6192" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-117617" status="VALID">
          <idno type="IdRef">026403498</idno>
          <idno type="ISNI">0000000123372892</idno>
          <idno type="ROR">https://ror.org/02k9vew78</idno>
          <orgName>Université Nice Sophia Antipolis (1965 - 2019)</orgName>
          <orgName type="acronym">UNS</orgName>
          <date type="start">1965-10-23</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Parc Valrose, 06100 Nice</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1039632" status="VALID">
          <idno type="IdRef">241035694</idno>
          <idno type="ROR">https://ror.org/019tgvf94</idno>
          <orgName>Université Côte d'Azur</orgName>
          <orgName type="acronym">UniCA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Parc Valrose, 28, avenue Valrose 06108 Nice Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://univ-cotedazur.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300297" status="VALID">
          <idno type="IdRef">026402971</idno>
          <idno type="ISNI">0000 0001 2158 1666</idno>
          <idno type="ROR">https://ror.org/014zrew76</idno>
          <orgName>Université d'Orléans</orgName>
          <orgName type="acronym">UO</orgName>
          <desc>
            <address>
              <addrLine>Château de la Source - Avenue du Parc Floral - BP 6749 - 45067 Orléans cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-orleans.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300113" status="VALID">
          <idno type="ROR">https://ror.org/05qsjq305</idno>
          <orgName>Centre Hospitalier Universitaire de Nice</orgName>
          <orgName type="acronym">CHU Nice</orgName>
          <desc>
            <address>
              <addrLine>30, Voie RomaineCS 51069 - 06001 Nice Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nice.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300155" status="VALID">
          <orgName>Hôpital l'Archet</orgName>
          <desc>
            <address>
              <addrLine>151 Route de Saint-Antoine de Ginestière, 06200 Nice</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nice.fr/nos-hopitaux/hopital-larchet</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300622" status="VALID">
          <orgName>IFR50</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-7569" status="VALID">
          <idno type="IdRef">026403838</idno>
          <idno type="ISNI">0000000121767954</idno>
          <idno type="ROR">https://ror.org/03hypw319</idno>
          <orgName>Université de Reims Champagne-Ardenne</orgName>
          <orgName type="acronym">URCA</orgName>
          <desc>
            <address>
              <addrLine>2 avenue Robert Schuman, 51100 Reims.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-reims.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300611" status="VALID">
          <orgName>IFR53</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>