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Article Dans Une Revue Journal of Immunology Année : 2007

CD8 T cell help for innate antitumor immunity.

Résumé

Innate immunity is considered to initiate adaptive antitumor responses. We demonstrate that monoclonal CD8 T lymphocytes reactive to tumor Ag P1A on P815 mastocytoma cells provide essential "help" to NK cells for rejection of P1A-deficient tumors. RAG-deficient mice have normal NK cells but do not reject either tumor. Reconstitution of these mice with P1A-specific T cells conferred resistance to both P1A-expressing and -deficient tumor cells provided they were present at the same site. Elimination of Ag-negative tumor variants required both activated T and NK cells. Gene expression profiling of NK cells infiltrating P1A-positive tumors in mice with specific CD8 T cells demonstrated an activated effector phenotype. However, CD8 T cell help to NK cells appeared ineffective for P1A-negative variants separated from the P1A-positive tumor. Local tumor Ag-specific T cell-NK cell collaboration results in the elimination of tumor cells whether they express or not the T cell tumor Ag epitope, thus containing the emergence of tumor escape variants before metastasis.

Domaines

Immunologie
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Dates et versions

hal-00297261 , version 1 (15-07-2008)

Identifiants

  • HAL Id : hal-00297261 , version 1
  • PUBMED : 17982055

Citer

Anil Shanker, Grégory Verdeil, Michel Buferne, Else-Marit Inderberg-Suso, Denis Puthier, et al.. CD8 T cell help for innate antitumor immunity.. Journal of Immunology, 2007, 179 (10), pp.6651-62. ⟨hal-00297261⟩

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