Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Immunology Année : 2007

Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor.

Résumé

Consistent with their function in immune surveillance, natural killer (NK) cells are distributed throughout lymphoid and nonlymphoid tissues. However, the mechanisms governing the steady-state trafficking of NK cells remain unknown. The lysophospholipid sphingosine 1-phosphate (S1P), by binding to its receptor S1P1, regulates the recirculation of T and B lymphocytes. In contrast, S1P5 is detected in the brain and regulates oligodendrocyte migration and survival in vitro. Here we show that S1P5 was also expressed in NK cells in mice and humans and that S1P5-deficient mice had aberrant NK cell homing during steady-state conditions. In addition, we found that S1P5 was required for the mobilization of NK cells to inflamed organs. Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P5.

Domaines

Immunologie

Dates et versions

hal-00297257 , version 1 (15-07-2008)

Identifiants

Citer

Thierry Walzer, Laura Chiossone, Julie Chaix, Andrew Calver, Claude Carozzo, et al.. Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor.. Nature Immunology, 2007, 8 (12), pp.1337-44. ⟨10.1038/ni1523⟩. ⟨hal-00297257⟩
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