Functions of natural killer cells. - Archive ouverte HAL Access content directly
Journal Articles Nature Immunology Year : 2008

Functions of natural killer cells.

(1, 2) , (1) , (1) , (1) , (1)
1
2

Abstract

Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage. Recent research highlights the fact that NK cells are also regulatory cells engaged in reciprocal interactions with dendritic cells, macrophages, T cells and endothelial cells. NK cells can thus limit or exacerbate immune responses. Although NK cells might appear to be redundant in several conditions of immune challenge in humans, NK cell manipulation seems to hold promise in efforts to improve hematopoietic and solid organ transplantation, promote antitumor immunotherapy and control inflammatory and autoimmune disorders.

Dates and versions

hal-00294184 , version 1 (08-07-2008)

Identifiers

Cite

Eric Vivier, Elena Tomasello, Myriam Baratin, Thierry Walzer, Sophie Ugolini. Functions of natural killer cells.. Nature Immunology, 2008, 9 (5), pp.503-10. ⟨10.1038/ni1582⟩. ⟨hal-00294184⟩

Collections

CNRS UNIV-AMU
361 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More