<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00291806</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T11:34:11+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">EDUC'AVK: Reduction of Oral Anticoagulant-related Adverse Events After Patient Education: A Prospective Multicenter Open Randomized Study.</title>
            <author role="aut">
              <persName>
                <forename type="first">Gilles</forename>
                <surname>Pernod</surname>
              </persName>
              <email type="md5">4016f65f8ef2b07d7ce677d2b9f73ccb</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">1367614</idno>
              <idno type="halauthorid" notation="string">250940-1367614</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6494-5984</idno>
              <affiliation ref="#struct-388317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">José</forename>
                <surname>Labarère</surname>
              </persName>
              <email type="md5">1a8f7ccb5bd17297b82ff42238a5b967</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">945776</idno>
              <idno type="halauthorid" notation="string">250976-945776</idno>
              <affiliation ref="#struct-388317"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jacqueline</forename>
                <surname>Yver</surname>
              </persName>
              <idno type="halauthorid">320665-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bernadette</forename>
                <surname>Satger</surname>
              </persName>
              <idno type="halauthorid">320666-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoit</forename>
                <surname>Allenet</surname>
              </persName>
              <email type="md5">762a7331d13b00d4192b9fd11ac15ba4</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">1449882</idno>
              <idno type="halauthorid" notation="string">320667-1449882</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9989-5101</idno>
              <idno type="IDREF">https://www.idref.fr/067288529</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5928-2014</idno>
              <idno type="VIAF">https://viaf.org/viaf/173040404</idno>
              <idno type="ISNI">http://isni.org/isni/0000000123308671</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=MpAC050AAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/132146094178400330966</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-5928-2014</idno>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Touffek</forename>
                <surname>Berremili</surname>
              </persName>
              <idno type="halauthorid">320668-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michèle</forename>
                <surname>Fontaine</surname>
              </persName>
              <idno type="halauthorid">320669-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guy</forename>
                <surname>Franco</surname>
              </persName>
              <idno type="halauthorid">320670-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean</forename>
                <surname>Bosson</surname>
              </persName>
              <email type="md5">012040f0cb3ec469b70d203dbdd88e68</email>
              <email type="domain">imag.fr</email>
              <idno type="idhal" notation="numeric">1349988</idno>
              <idno type="halauthorid" notation="string">804448-1349988</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0967-6026</idno>
              <idno type="IDREF">https://www.idref.fr/06012282X</idno>
              <idno type="ISNI">http://isni.org/isni/000000035906575X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6378-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAP-5163-2020</idno>
              <idno type="VIAF">https://viaf.org/viaf/9171184718147771676</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6378-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAP-5163-2020</idno>
              <affiliation ref="#struct-388317"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jose</forename>
                <surname>Labarere</surname>
              </persName>
              <email type="md5">1a8f7ccb5bd17297b82ff42238a5b967</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2008-06-30 09:46:42</date>
              <date type="whenModified">2025-09-27 18:43:44</date>
              <date type="whenReleased">2008-06-30 09:46:42</date>
              <date type="whenProduced">2008-06-20</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518037"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="123487">
                <persName>
                  <forename>Jose</forename>
                  <surname>Labarere</surname>
                </persName>
                <email type="md5">1a8f7ccb5bd17297b82ff42238a5b967</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00291806</idno>
            <idno type="halUri">https://hal.science/hal-00291806</idno>
            <idno type="halBibtex">pernod:hal-00291806</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of General Internal Medicine&lt;/i&gt;, 2008, epub ahead of print. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s11606-008-0690-1"&gt;&amp;#x27E8;10.1007/s11606-008-0690-1&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of General Internal Medicine, 2008, epub ahead of print. &amp;#x27E8;10.1007/s11606-008-0690-1&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-THEMAS" corresp="TIMC-IMAG">ThEMAS : Techniques pour l'Evaluation et la Modélisation des Actions de Santé</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">EDUC'AVK: Reduction of Oral Anticoagulant-related Adverse Events After Patient Education: A Prospective Multicenter Open Randomized Study.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Gilles</forename>
                    <surname>Pernod</surname>
                  </persName>
                  <email type="md5">4016f65f8ef2b07d7ce677d2b9f73ccb</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">1367614</idno>
                  <idno type="halauthorid" notation="string">250940-1367614</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6494-5984</idno>
                  <affiliation ref="#struct-388317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">José</forename>
                    <surname>Labarère</surname>
                  </persName>
                  <email type="md5">1a8f7ccb5bd17297b82ff42238a5b967</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">945776</idno>
                  <idno type="halauthorid" notation="string">250976-945776</idno>
                  <affiliation ref="#struct-388317"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jacqueline</forename>
                    <surname>Yver</surname>
                  </persName>
                  <idno type="halauthorid">320665-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bernadette</forename>
                    <surname>Satger</surname>
                  </persName>
                  <idno type="halauthorid">320666-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoit</forename>
                    <surname>Allenet</surname>
                  </persName>
                  <email type="md5">762a7331d13b00d4192b9fd11ac15ba4</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">1449882</idno>
                  <idno type="halauthorid" notation="string">320667-1449882</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9989-5101</idno>
                  <idno type="IDREF">https://www.idref.fr/067288529</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5928-2014</idno>
                  <idno type="VIAF">https://viaf.org/viaf/173040404</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000123308671</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=MpAC050AAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/132146094178400330966</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-5928-2014</idno>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Touffek</forename>
                    <surname>Berremili</surname>
                  </persName>
                  <idno type="halauthorid">320668-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michèle</forename>
                    <surname>Fontaine</surname>
                  </persName>
                  <idno type="halauthorid">320669-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guy</forename>
                    <surname>Franco</surname>
                  </persName>
                  <idno type="halauthorid">320670-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean</forename>
                    <surname>Bosson</surname>
                  </persName>
                  <email type="md5">012040f0cb3ec469b70d203dbdd88e68</email>
                  <email type="domain">imag.fr</email>
                  <idno type="idhal" notation="numeric">1349988</idno>
                  <idno type="halauthorid" notation="string">804448-1349988</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0967-6026</idno>
                  <idno type="IDREF">https://www.idref.fr/06012282X</idno>
                  <idno type="ISNI">http://isni.org/isni/000000035906575X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6378-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAP-5163-2020</idno>
                  <idno type="VIAF">https://viaf.org/viaf/9171184718147771676</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6378-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAP-5163-2020</idno>
                  <affiliation ref="#struct-388317"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15520</idno>
                <idno type="issn">0884-8734</idno>
                <idno type="eissn">1525-1497</idno>
                <title level="j">Journal of General Internal Medicine</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="pp">epub ahead of print</biblScope>
                  <date type="datePub">2008-06-20</date>
                  <date type="dateEpub">2008-06-20</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s11606-008-0690-1</idno>
              <idno type="pubmed">18566863</idno>
              <idno type="pubmedcentral">PMC2518037</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND: Long-term oral anticoagulation treatment is associated with potential morbidity. Insufficient patient education is linked to poorly controlled anticoagulation. However the impact of a specific educational program on anticoagulation related morbidity remains unknown. OBJECTIVE: To evaluate the effect of an oral anticoagulation patient education program in reducing both hemorrhagic and recurrent thrombotic complications. DESIGN/PARTICIPANTS: We conducted a prospective, multicenter open randomized study, comparing an interventional group who received a specific oral anticoagulation treatment educational program with a control group. Eligible patients were older than 18 and diagnosed as having deep vein thrombosis or pulmonary embolism requiring therapy with a vitamin K antagonist for 3 months or more. Our primary outcome was the occurrence of hemorrhagic or thromboembolic events. RESULTS: During the 3-month follow-up the main outcome criteria were observed 20 times (6.6% of patients), 5 (3.1%) in the experimental and 15 (10.6%) in the control group. Consequently, in multivariate analysis, the cumulative risk reduction in the experimental group was statistically significant (OR 0.25, 95% CI 0.1 - 0.7, p &lt; 0.01). CONCLUSIONS: Patient education using an educational program reduced VKA-related adverse event rates.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-388317" status="OLD">
          <orgName>Techniques pour l'Evaluation et la Modélisation des Actions de la Santé</orgName>
          <orgName type="acronym">TIMC-IMAG-ThEMAS</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/ThEMAS</ref>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>