Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice.
Résumé
Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P< 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention.
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2001-Parnaud-Tache-Peiffer-Corpet-PLU-Brit.J.Cancer-NOT-protec.pdf (610.89 Ko)
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