Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum.
Résumé
The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range.