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Article Dans Une Revue Journal of Natural Products Année : 2006

Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum.

Résumé

The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range.

Dates et versions

hal-00271927 , version 1 (10-04-2008)

Identifiants

Citer

Véronique Eparvier, van Hung Nguyen, Odile Thoison, Marie-Thérèse Martin, Thierry Sévenet, et al.. Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum.. Journal of Natural Products, 2006, 69 (9), pp.1289-94. ⟨10.1021/np060168j⟩. ⟨hal-00271927⟩
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