The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2007

The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes.

Résumé

A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity-selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.

Domaines

Chimie organique
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Dates et versions

hal-00259076 , version 1 (26-02-2008)

Identifiants

  • HAL Id : hal-00259076 , version 1
  • PUBMED : 18019527

Citer

Hélène Bertrand, David Monchaud, Anne de Cian, Régis Guillot, Jean-Louis Mergny, et al.. The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes.. Organic & Biomolecular Chemistry, 2007, 5 (16), pp.2555-9. ⟨hal-00259076⟩
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