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Article Dans Une Revue Human Genetics Année : 2005

Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec.

Vania Yotova
  • Fonction : Auteur
Damian Labuda
  • Fonction : Auteur
Ewa Zietkiewicz
  • Fonction : Auteur
Dominik Gehl
  • Fonction : Auteur
Alan Lovell
  • Fonction : Auteur
Jean-François Lefebvre
  • Fonction : Auteur
Stéphane Bourgeois
  • Fonction : Auteur
Emilie Lemieux-Blanchard
  • Fonction : Auteur
Marcin Labuda
  • Fonction : Auteur
Hélène Vézina
  • Fonction : Auteur
Louis Houde
  • Fonction : Auteur
Marc Tremblay
  • Fonction : Auteur
Bruno Toupance
Evelyne Heyer
Thomas J. Hudson
  • Fonction : Auteur
Claude Laberge
  • Fonction : Auteur

Résumé

Founder effects are largely responsible for changes in frequency profiles of genetic variants in local populations or isolates. They are often recognized by elevated incidence of certain hereditary disorders as observed in regions of Charlevoix and Saguenay-Lac-Saint-Jean (SLSJ) in Northeastern Quebec. Dominantly transmitted myotonic dystrophy (DM1) is highly prevalent in SLSJ where its carrier rate reaches 1/550, compared with 1/5,000 to 1/50,000 elsewhere. To shed light on the origin of DM1 in this region, we have screened 50 nuclear DM1 families from SLSJ and studied the genetic variation in a 2.05 Mb (2.9 cM) segment spanning the site of the expansion mutation. The markers analyzed included 22 biallelic SNPs and two microsatellites. Among 50 independent DM1 chromosomes, we distinguished ten DM1-associated haplotypes and grouped them into three haplotype families, A, B and C, based on the relevant extent of allele sharing between them. To test whether the data were consistent with a single entry of the mutation into SLSJ, we evaluated the age of the founder effect from the proportion of recombinant haplotypes. Taking the prevalent haplotype A1_21 (58%) as ancestral to all the disease-associated haplotypes in this study, the estimated age of the founder effect was 19 generations, long predating the colonization of Nouvelle-France. In contrast, considering A1_21 as ancestral to the haplotype family A only, yielded the estimated founder age of nine generations, consistent with the settlement of Charlevoix at the turn of 17th century and subsequent colonization of SLSJ. We conclude that it was the carrier of haplotype A (present day carrier rate of 1/730) that was a "driver" of the founder effect, while minor haplotypes B and C, with corresponding carrier rates of 1/3,000 and 1/10,000, respectively, contribute DM1 to the incidence level known in other populations. Other studies confirm that this might be a general scenario in which a major "driver" mutation/haplotype issued from a founder effect is found accompanied by distinct minor mutations/haplotypes occurring at background population frequencies.

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Dates et versions

hal-00216119 , version 1 (24-01-2008)

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Citer

Vania Yotova, Damian Labuda, Ewa Zietkiewicz, Dominik Gehl, Alan Lovell, et al.. Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec.. Human Genetics, 2005, 117 (2-3), pp.177-187. ⟨10.1007/s00439-005-1298-8⟩. ⟨hal-00216119⟩
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