From the first to the fourth century AD, the Gallo-Roman town of Oedenburg developed in the alluvial landscape of the southern Upper Rhine Graben. Throughout this period, the landscape mosaic, composed of palaeochannels, stable palaeoislands and river terraces, continued to evolve. A district of this town, situated on a lateral Rhine channel system, was archaeologically excavated. Largescale excavation and cross-section analysis provide evidence of changing fluvial conditions during the period under study. At about AD 20 or earlier, this lateral part of the floodplain, affected by very fine sedimentation, was occupied by moribund marshy palaeochannels. When the first Gallo-Roman settlers occupied the site, they filled parts of the channels with woven brushwood in order to create an efficient circulation surface. The sedimentary infill of this palaeochannel records four different flood deposits interlayered with dated anthropogenic units (pavements, road embankments, and other structures). Archaeological analysis and dendrochronological dating indicate that these four flooding events occurred during a short time period between AD 20 and AD 145/146. These geoarchaeological observations focus on floods that do not seem to have significantly affected human occupation in this part of the Rhine floodplain. These results are set in the broader context of the Rhine catchment and the Alps.