Molecular modeling study for a novel structured oligomer subunit selection: the example of 2-aminomethyl-phenyl-acetic acid

Oligomers derived from dipeptide mimics were selected by computational study for their suitability to fold in ordered structures. After selection of a monomeric unit, short oligomers were synthesized and analyzed by NMR and IR. Oligomers built from 2-aminomethyl-phenyl-acetic acid were shown to adopt a helical structure stabilized by 10-membered ring hydrogen bonds

Mots clés

Helical oligomers H NMR and IR studies Molecular modeling Dipeptide mimics Poly(AMPA)

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Génie des procédés

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https://hal.science/hal-00199097

Soumis le : mardi 18 décembre 2007-14:37:20

Dernière modification le : lundi 17 juin 2024-17:58:49

Dates et versions

hal-00199097 , version 1 (18-12-2007)

Identifiants

HAL Id : hal-00199097 , version 1
DOI : 10.1016/j.tetlet.2007.01.032

Citer

Marie-Christine Averlant-Petit, Nicolas Raynal, Gilbert Bergé, Claude Didierjean, Michel Marraud, et al.. Molecular modeling study for a novel structured oligomer subunit selection: the example of 2-aminomethyl-phenyl-acetic acid. Tetrahedron Letters, 2007, 48 (10), pp.1787-1790. ⟨10.1016/j.tetlet.2007.01.032⟩. ⟨hal-00199097⟩

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