Adding self-renewal in committed erythroid progenitors improves the biological relevance of a mathematical model of erythropoiesis. - Archive ouverte HAL Access content directly
Journal Articles Journal of Theoretical Biology Year : 2008

Adding self-renewal in committed erythroid progenitors improves the biological relevance of a mathematical model of erythropoiesis.

Abstract

We propose a new mathematical model of erythropoiesis that takes a positive feedback of erythrocytes on progenitor apoptosis into account, and incorporates a negative feedback of erythrocytes on progenitor self-renewal. The resulting model is a system of age-structured equations that reduces to a system of delay differential equations where the delays account for progenitor compartment duration and cell cycle length. We compare this model with experimental data on an induced-anemia in mice that exhibit damped oscillations of the hematocrit before it returns to equilibrium. When we assume no self-renewal of progenitors, we obtain an inaccurate fitting of the model with experimental data. Adding self-renewal in the progenitor compartment gives better approximations, with the main features of experimental data correctly fitted. Our results indicate the importance of progenitor self-renewal in the modelling of erythropoiesis. Moreover, the model makes testable predictions on the lifespan of erythrocytes confronted to a severe anemia, and on the progenitors behavior.

Dates and versions

hal-00194422 , version 1 (06-12-2007)

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Fabien Crauste, Laurent Pujo-Menjouet, Stéphane Génieys, Clément Molina, Olivier Gandrillon. Adding self-renewal in committed erythroid progenitors improves the biological relevance of a mathematical model of erythropoiesis.. Journal of Theoretical Biology, 2008, 250, pp.322-338. ⟨10.1016/j.jtbi.2007.09.041⟩. ⟨hal-00194422⟩
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