Messenger RNA conformations in the ribosomal E site revealed by X-ray crystallography. - Archive ouverte HAL Access content directly
Journal Articles EMBO Reports Year : 2007

Messenger RNA conformations in the ribosomal E site revealed by X-ray crystallography.

Abstract

A comparison of messenger RNA in X-ray crystal structures of 70S ribosomal complexes in the initiation, post-initiation and elongation states of translation shows distinct conformational differences in the exit (E) codon. Here, we present structural evidence indicating that, after the initiation event, the E codon nucleotides relax and form a classical A-helical conformation. This conformation is similar to that of the P and A codons, and is favourable for establishing Watson-Crick interactions with the anticodon of E-site transfer RNA.

Dates and versions

hal-00189152 , version 1 (20-11-2007)

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Lasse Jenner, Bernard Rees, Marat M. Yusupov, Gulnara Yusupova. Messenger RNA conformations in the ribosomal E site revealed by X-ray crystallography.. EMBO Reports, 2007, 8 (9), pp.846-50. ⟨10.1038/sj.embor.7401044⟩. ⟨hal-00189152⟩
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