Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning. - Archive ouverte HAL
Journal Articles Developmental Dynamics Year : 2007

Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.

Christelle Matis
  • Function : Author
Sophie Remacle
  • Function : Author
Xavier Lampe
  • Function : Author
Françoise Gofflot
  • Function : Author
Jacques J Picard
  • Function : Author
René Rezsohazy
  • Function : Author

Abstract

The embryonic functions of Hox proteins have been extensively investigated in several animal phyla. These transcription factors act as selectors of developmental programmes, to govern the morphogenesis of multiple structures and organs. However, despite the variety of morphogenetic processes Hox proteins are involved in, only a limited set of their target genes has been identified so far. To find additional targets, we used a strategy based upon the simultaneous overexpression of Hoxa2 and its cofactors Pbx1 and Prep in a cellular model. Among genes whose expression was upregulated, we identified LMO1, which codes for an intertwining LIM-only factor involved in protein-DNA oligomeric complexes. By analysing its expression in Hox knockout mice, we show that Lmo1 is differentially regulated by Hoxa2 and Hoxb2, in specific columns of hindbrain neuronal progenitors. These results suggest that Lmo1 takes part in a Hox paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning.

Dates and versions

hal-00189148 , version 1 (20-11-2007)

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Cite

Christelle Matis, Franck Oury, Sophie Remacle, Xavier Lampe, Françoise Gofflot, et al.. Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.. Developmental Dynamics, 2007, 236 (9), pp.2675-84. ⟨10.1002/dvdy.21266⟩. ⟨hal-00189148⟩
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