Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Metabolism Année : 2006

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

Angelina Rodriguez
  • Fonction : Auteur
Mohammed Selloum
Francisco J Diez-Guerra
  • Fonction : Auteur
Juana María Flores
  • Fonction : Auteur
Manuel Serrano
María T Diaz-Meco
  • Fonction : Auteur
Jorge Moscat
  • Fonction : Auteur

Résumé

Signaling cascades that control adipogenesis are essential in the regulation of body weight and obesity. The adaptor p62 controls pathways that modulate cell differentiation. We report here that p62(-/-) mice develop mature-onset obesity, leptin resistance, as well as impaired glucose and insulin intolerance. The metabolic rate was significantly reduced in p62(-/-) nonobese mice, which displayed increased mRNA levels of PPAR-gamma and reduced levels of UCP-1 in adipose tissue. Basal activity of ERK was enhanced in fat from nonobese mutant mice. Embryo fibroblasts from p62(-/-) mice differentiated better than the wild-type controls into adipocytes, which was abrogated by pharmacological inhibition of the ERK pathway. p62 is induced during adipocyte differentiation and inhibits ERK activation by direct interaction. We propose that p62 normally antagonizes basal ERK activity and adipocyte differentiation and that its loss leads to the hyperactivation of ERK that favors adipogenesis and obesity.

Dates et versions

hal-00188124 , version 1 (15-11-2007)

Identifiants

Citer

Angelina Rodriguez, Angeles Durán, Mohammed Selloum, Marie-France Champy, Francisco J Diez-Guerra, et al.. Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.. Cell Metabolism, 2006, 3 (3), pp.211-22. ⟨10.1016/j.cmet.2006.01.011⟩. ⟨hal-00188124⟩
54 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More