Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Development (Cambridge, England) Année : 2005

Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells.

Résumé

Using genetic approaches in the mouse, we show that the primary target tissue of retinoic acid (RA) action during eye morphogenesis is not the retina nor the corneal ectoderm, which both express RA-synthesizing retinaldehyde dehydrogenases (RALDH1 and RALDH3), but the neural crest cell-derived periocular mesenchyme (POM), which is devoid of RALDH. In POM, the effects of the paracrine RA signal are mediated by the nuclear RA receptors heterodimers RXRalpha/RARbeta and RXRalpha/RARgamma. These heterodimers appear to control: (1) the remodeling of the POM through activation of Eya2-related apoptosis; (2) the expression of Foxc1 and Pitx2, which play crucial roles in anterior eye segment development; and (3) the growth of the ventral retina. We additionally show that RALDH1 and RALDH3 are the only enzymes that are required for RA synthesis in the eye region from E10.5 to E13.5, and that patterning of the dorsoventral axis of the retina does not require RA.

Dates et versions

hal-00187693 , version 1 (15-11-2007)

Identifiants

Citer

Nicolas Matt, Valérie Dupé, Jean-Marie Garnier, Christine Dennefeld, Pierre Chambon, et al.. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells.. Development (Cambridge, England), 2005, 132 (21), pp.4789-800. ⟨10.1242/dev.02031⟩. ⟨hal-00187693⟩
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