In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue NeuroImage Année : 2007

In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.

Résumé

This study has shown that murine monocytes/macrophages (Mo/Ma) can be labeled simply and efficiently with large, green-fluorescent, micrometer-sized particles of iron-oxide (MPIO). Neither size nor proliferation rate of the Mo/Ma is significantly affected by this labeling. The labeled Mo/Ma have been administered intravenously to rats that had developed a glioma following stereotactic injection of C6 cells. The labeled Mo/Ma were shown to target the brain tumors, a process that could be monitored non-invasively using T2*-weighted MRI. MRI observations were confirmed by Prussian blue staining, lectin staining and fluorescence histology. Overall, the results of this study suggest that the use of Mo/Ma may be envisaged in the clinic for vectorizing therapeutic agents towards gliomas.

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Dates et versions

hal-00178542 , version 1 (11-10-2007)

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Samuel Valable, Emmanuel L Barbier, Myriam Bernaudin, Simon Roussel, Christoph Segebarth, et al.. In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.. NeuroImage, 2007, 37 Suppl 1, pp.S47-58. ⟨10.1016/j.neuroimage.2007.05.041⟩. ⟨hal-00178542⟩
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