Malignant breast tumors after radiotherapy for a first cancer during childhood. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Oncology Année : 2005

Malignant breast tumors after radiotherapy for a first cancer during childhood.

Emmanuel Grimaud
  • Fonction : Auteur
Xavier Panis
  • Fonction : Auteur
Nicolas Daly-Schveitzer
  • Fonction : Auteur

Résumé

PURPOSE: To assess the specific role of treatment and type of first cancer (FC) in the risk of long-term subsequent breast cancer (BC) among childhood cancer survivors. PATIENTS AND METHODS: In a cohort of 1,814 3-year female survivors treated between 1946 and 1986 in eight French and English centers, data on chemotherapy and radiotherapy were collected. Individual estimation of radiation dose to each breast was performed for the 1,258 patients treated by external radiotherapy; mean dose to breast was 5.06 Gy (range, 0.0 to 88.0 Gy) delivered in 20 fractions (mean). RESULTS: Mean follow-up was 16 years; 16 patients developed a clinical BC, 13 after radiotherapy. The cumulative incidence of BC was 2.8% (95% CI, 1.0% to 4.5%) 30 years after the FC and 5.1% (95% CI, 2.1% to 8.2%) at the age of 40 years. The annual excess incidence increased as age increased, whereas the standardized incidence ratio decreased. On average, each Gray unit received by any breast increased the excess relative risk of BC by 0.13 (< 0.0 to 0.75). After stratification on castration and attained age, and adjusting for radiation dose, FC type, and chemotherapy, a higher risk of a subsequent BC was associated with Hodgkin's disease (relative risk, 7.0; 95% CI, 1.4 to 30.9). CONCLUSION: The reported high risk of BC after childhood Hodgkin's disease treatment seems to be due not only to a higher radiation dose to the breasts, but also to a specific susceptibility.

Dates et versions

hal-00177211 , version 1 (05-10-2007)

Identifiants

Citer

Catherine Guibout, Elisabeth Adjadj, Carole Rubino, Akthar Shamsaldin, Emmanuel Grimaud, et al.. Malignant breast tumors after radiotherapy for a first cancer during childhood.. Journal of Clinical Oncology, 2005, 23 (1), pp.197-204. ⟨10.1200/JCO.2005.06.225⟩. ⟨hal-00177211⟩
293 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More