Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2007

Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.

Nicolas Papon
Martine Florent
  • Fonction : Auteur
Stéphanie Gibot-Leclerc
Dorothée Jean
  • Fonction : Auteur
Christiane Chastin
  • Fonction : Auteur
Jean Villard
  • Fonction : Auteur
Florence Chapeland-Leclerc

Résumé

Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.

Dates et versions

hal-00169317 , version 1 (03-09-2007)

Identifiants

Citer

Nicolas Papon, Thierry Noël, Martine Florent, Stéphanie Gibot-Leclerc, Dorothée Jean, et al.. Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.. Antimicrobial Agents and Chemotherapy, 2007, 51 (1), pp.369-71. ⟨10.1128/AAC.00824-06⟩. ⟨hal-00169317⟩

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