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Article Dans Une Revue FEBS Letters Année : 2007

UCP2 is a mitochondrial transporter with an unusual very short half-life.

Résumé

This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half-life close to 30min, compared to 30h for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability.

Dates et versions

hal-00167523 , version 1 (21-08-2007)

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Citer

Sophie Rousset, Julien Mozo, Geneviève Dujardin, Yalin Emre, Sandrine Masscheleyn, et al.. UCP2 is a mitochondrial transporter with an unusual very short half-life.. FEBS Letters, 2007, 581 (3), pp.479-82. ⟨10.1016/j.febslet.2007.01.010⟩. ⟨hal-00167523⟩
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