Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2007

Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.

Résumé

Amidoxime and O-substituted derivatives of the bis-alkylamidine 1,12-bis(N,N'-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration.

Dates et versions

hal-00167429 , version 1 (20-08-2007)

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Citer

Mahama Ouattara, Sharon Wein, Michèle Calas, Yen Vo-Hoang, Henri Vial, et al.. Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.. Bioorganic and Medicinal Chemistry Letters, 2007, 17 (3), pp.593-6. ⟨10.1016/j.bmcl.2006.11.013⟩. ⟨hal-00167429⟩
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