The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Immunity Année : 2001

The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation.

Résumé

Dynamic interactions between membrane and cytoskeleton components are crucial for T cell antigen recognition and subsequent cellular activation. We report here that the membrane-microfilament linker ezrin plays an important role in these processes. First, ezrin relocalizes to the contact area between T cells and stimulatory antigen-presenting cells (APCs), accumulating in F-actin-rich membrane protrusions at the periphery of the immunological synapse. Second, T cell receptor (TCR)-mediated intracellular signals are sufficient to induce ezrin relocalization, indicating that this protein is an effector of TCR signaling. Third, overexpression of the membrane binding domain of ezrin perturbs T cell receptor clustering in the T cell-APC contact area and inhibits the activation of nuclear factor for activated T cells (NF-AT).

Dates et versions

hal-00161327 , version 1 (10-07-2007)

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Citer

A. Roumier, J. C. Olivo-Marin, Monique Arpin, F. Michel, M. Martin, et al.. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation.. Immunity, 2001, 15 (5), pp.715-28. ⟨10.1016/S1074-7613(01)00225-4⟩. ⟨hal-00161327⟩
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