Genome sequence of Aedes aegypti, a major arbovirus vector.
Vishvanath Nene
(1)
,
Jennifer R. Wortman
(1)
,
Daniel Lawson
(2)
,
Brian Haas
(1)
,
Chinnappa Kodira
(3)
,
Zhijian Jake Tu
(4)
,
Brendan Loftus
(1, 5)
,
Zhijong Xi
(6)
,
Karyn Megy
(2)
,
Manfred Grabherr
(3)
,
Quinghu Ren
(1)
,
Evgeny M. Zdobnov
(7)
,
Neil F. Lobo
(8)
,
Kathryn S. Campbell
(9)
,
Susan E. Brown
(10)
,
Maria F. Bonaldo
(11)
,
Jingsong Zhu
(12)
,
Steven P. Sinkins
(13)
,
David G. Hogenkamp
(14)
,
Paulo Amedo
(1)
,
Peter Arsenburger
(12)
,
Peter W. Atkinson
(12)
,
Shelby Bidwell
(1)
,
Jim Biedler
(4)
,
Ewan Birney
(2)
,
Robert V. Bruggner
(8)
,
Javier Costas
(15)
,
Monique R. Coy
(4)
,
Jonathan Crabtree
(1)
,
Matt Crawford
(3)
,
Becky Debruyn
(8)
,
David Decaprio
(3)
,
Karin Eiglmeier
(16)
,
Eric Eisenstadt
(1)
,
Hamza El-Dorry
(17)
,
William M. Gelbar
(9)
,
Suely L. Gomes
(17)
,
Martin Hammond
(2)
,
Linda I. Hannick
(1)
,
James R. Hogan
(8)
,
Michael H. Holmes
(1)
,
David Jaffe
(3)
,
Spencer J. Johnston
(18)
,
Ryan C. Kennedy
(8)
,
Hean Koo
(1)
,
Saul Kravitz
(19)
,
Evgenia V. Kriventseva
(20)
,
David Kulp
(21)
,
Kurt Labutti
(3)
,
Edward Lee
(1)
,
Song Li
(4)
,
Diane D. Lovin
(8)
,
Chunhong Mao
(4)
,
Evan Mauceli
(3)
,
Carlos F. M. Menck
(22)
,
Jason R. Miller
(1)
,
Philip Montgomery
(3)
,
Akio Mori
(8)
,
Ana L. Nascimento
(23)
,
Horacio F. Naveira
(24)
,
Chad Nusbaum
(3)
,
Sinéad B. O'Leary
(3)
,
Joshua Orvis
(1)
,
Mihaela Pertea
(25)
,
Hadi Quesneville
(26)
,
Kyanne R. Reidenbach
(14)
,
Yu-Hui Rogers
(19)
,
Charles W. Roth
(16)
,
Jennifer R. Schneider
(8)
,
Michael Schatz
(25)
,
Martin Shumway
(1)
,
Mario Stanke
(27)
,
Eric O. Stinson
(8)
,
Jose M. C. Tubio
(28)
,
Janice P. Vanzee
(14)
,
Sergio Verjovski-Almeida
(17)
,
Doreen Werner
(29)
,
Owen White
(1)
,
Stefan Wyder
(20)
,
Qi Zeng
(3)
,
Qi Zhao
(1)
,
Yongmei Zhao
(1)
,
Catherine A. Hill
(14)
,
Alexander S. Raikhel
(12)
,
Marcelo B. Soares
(11)
,
Dennis L. Knudson
(10)
,
Norman H. Lee
(30)
,
James Galagan
(3)
,
Steven L. Salzberg
(25)
,
Ian T. Paulsen
(1)
,
George Dimopoulos
(6)
,
Frank H. Collins
(8)
,
Birren Bruce
(3)
,
Claire M. Fraser-Liggett
(1)
,
David W. Severson
(8)
1
TIGR -
The Institute for Genomic Research
2 EMBL-EBI - European Bioinformatics Institute [Hinxton]
3 BROAD INSTITUTE - Broad Institute of MIT and Harvard
4 Virginia Polytechnic Institute and State University [Blacksburg]
5 UCD - University College Dublin [Dublin]
6 Johns Hopkins Bloomberg School of Public Health [Baltimore]
7 University of Geneva Medical School
8 UND - University of Notre Dame [Indiana]
9 Harvard University
10 College of Agricultural Sciences Colorado State University
11 Northwestern University [Evanston]
12 UC Riverside - University of California [Riverside]
13 AOPP - Department of Atmospheric, Oceanic and Planetary Physics [Oxford]
14 Purdue University [West Lafayette]
15 Centro Nacional de Genotipado Fundación Pública Galega de Medicina Xenómica Hospital Clínico Universitario de Santiago
16 IP - Institut Pasteur [Paris]
17 Universidade de Sao Paulo Instituto de Quimica
18 Texas A&M University [College Station]
19 Joint Technology Center,
20 University of Geneva Medical School
21 UMass Amherst - University of Massachusetts [Amherst]
22 Universidade de Sao Paulo, Institute of Biomedical Sciences
23 Instituto Butantan = Butantan Institute
24 Universidade da Coruña
25 University of Maryland [College Park]
26 IJM (UMR_7592) - Institut Jacques Monod
27 UC Santa Cruz - University of California [Santa Cruz]
28 Complexo Hospitalario Universitario de Santiago
29 Georg-August-University = Georg-August-Universität Göttingen
30 George Washington University Medical Center
2 EMBL-EBI - European Bioinformatics Institute [Hinxton]
3 BROAD INSTITUTE - Broad Institute of MIT and Harvard
4 Virginia Polytechnic Institute and State University [Blacksburg]
5 UCD - University College Dublin [Dublin]
6 Johns Hopkins Bloomberg School of Public Health [Baltimore]
7 University of Geneva Medical School
8 UND - University of Notre Dame [Indiana]
9 Harvard University
10 College of Agricultural Sciences Colorado State University
11 Northwestern University [Evanston]
12 UC Riverside - University of California [Riverside]
13 AOPP - Department of Atmospheric, Oceanic and Planetary Physics [Oxford]
14 Purdue University [West Lafayette]
15 Centro Nacional de Genotipado Fundación Pública Galega de Medicina Xenómica Hospital Clínico Universitario de Santiago
16 IP - Institut Pasteur [Paris]
17 Universidade de Sao Paulo Instituto de Quimica
18 Texas A&M University [College Station]
19 Joint Technology Center,
20 University of Geneva Medical School
21 UMass Amherst - University of Massachusetts [Amherst]
22 Universidade de Sao Paulo, Institute of Biomedical Sciences
23 Instituto Butantan = Butantan Institute
24 Universidade da Coruña
25 University of Maryland [College Park]
26 IJM (UMR_7592) - Institut Jacques Monod
27 UC Santa Cruz - University of California [Santa Cruz]
28 Complexo Hospitalario Universitario de Santiago
29 Georg-August-University = Georg-August-Universität Göttingen
30 George Washington University Medical Center
Kurt Labutti
- Fonction : Auteur
- PersonId : 758166
- ORCID : 0000-0002-5838-1972
Edward Lee
- Fonction : Auteur
- PersonId : 758167
- ORCID : 0000-0003-0418-1454
Hadi Quesneville
- Fonction : Auteur
- PersonId : 736048
- IdHAL : hadi-quesneville
- ORCID : 0000-0003-3001-4908
- IdRef : 137542860
Sergio Verjovski-Almeida
- Fonction : Auteur
- PersonId : 758168
- ORCID : 0000-0002-6356-2401
James Galagan
- Fonction : Auteur
- PersonId : 758169
- ORCID : 0000-0003-0542-3291
Résumé
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.