Direct investigation of the vectorization properties of amphiphilic cyclodextrins in phospholipid films
Résumé
Phospholipids form very stable Newton Black Films which have some similar properties of real biological membrane. Recently, new cyclodextrin derivatives have been synthesised and were shown to exhibit strong amphiphilic properties. In this paper, we simulate the action on phospholipids of these new amphiphilic cyclodextrins. Mixed phospholipids/cyclodextrin derivatives films were prepared and studied using X-ray reflectivity for various phospholipids/ cyclodextrins ratios. A molar ratio of 3 affords a highly stable film for which the molecular structure has been investigated in details. The cyclodextrin molecular carrier property is also addressed through the addition of a neuroleptic drug: Dosulepin, to this complex film architecture, as an example of potential application.