Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia. - Archive ouverte HAL Access content directly
Journal Articles Nature Year : 2006

Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia.

Jean-Marc Aury
Olivier Jaillon
Olivier Arnaiz
Isabelle Blanc
Roland Kissmehl
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  • PersonId : 834786
Julie Poulain
Philippe Dessen
Eric Meyer
Jean Cohen
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  • PersonId : 838156
Patrick Wincker

Abstract

The duplication of entire genomes has long been recognized as having great potential for evolutionary novelties, but the mechanisms underlying their resolution through gene loss are poorly understood. Here we show that in the unicellular eukaryote Paramecium tetraurelia, a ciliate, most of the nearly 40,000 genes arose through at least three successive whole-genome duplications. Phylogenetic analysis indicates that the most recent duplication coincides with an explosion of speciation events that gave rise to the P. aurelia complex of 15 sibling species. We observed that gene loss occurs over a long timescale, not as an initial massive event. Genes from the same metabolic pathway or protein complex have common patterns of gene loss, and highly expressed genes are over-retained after all duplications. The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints.

Dates and versions

hal-00132091 , version 1 (20-02-2007)

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Jean-Marc Aury, Olivier Jaillon, L. Duret, Benjamin Noel, Claire Jubin, et al.. Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia.. Nature, 2006, 444 (7116), pp.171-8. ⟨10.1038/nature05230⟩. ⟨hal-00132091⟩
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