Article Dans Une Revue Nature Neuroscience Année : 2005

Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

Résumé

L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.

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hal-00131279 , version 1 (16-02-2007)

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Eric Burguiere, Angelo Arleo, Mohammad Reza Hojjati, Ype Elgersma, Chris I de Zeeuw, et al.. Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?. Nature Neuroscience, 2005, 8 (10), pp.1292-4. ⟨10.1038/nn1532⟩. ⟨hal-00131279⟩
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