LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development. - Archive ouverte HAL
Article Dans Une Revue Molecular and Biochemical Parasitology Année : 2005

LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development.

Résumé

As the malarial parasite Plasmodium falciparum develops inside the erythrocyte, parasite-derived membrane structures, referred to as Maurer's clefts, play an important role in parasite development by delivering parasite proteins to the host cell surface, and participating in the assembly of the cytoadherence complex, essential for the pathogenesis of cerebral malaria. PfSBP1 is an integral membrane protein of the clefts, interacting with an erythrocyte cytosolic protein, identified here as the human Lantibiotic synthetase component C-like protein LANCL1. LANCL1 is specifically recruited to the surface of Maurer's clefts in P. falciparum mature blood stages. We propose that the interaction between PfSBP1 and LANCL1 is central for late steps of the parasite development to prevent premature rupture of the red blood cell membrane.

Domaines

Parasitologie

Dates et versions

hal-00126405 , version 1 (24-01-2007)

Identifiants

Citer

Thierry Blisnick, Laetitia Vincensini, Jean Christophe Barale, Abdelkader Namane, Catherine Braun Breton. LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development.. Molecular and Biochemical Parasitology, 2005, 141 (1), pp.39-47. ⟨10.1016/j.molbiopara.2005.01.013⟩. ⟨hal-00126405⟩

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