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Article Dans Une Revue Bioinformatics Année : 2005

VarMixt: efficient variance modelling for the differential analysis of replicated gene expression data

Résumé

Motivation: Identifying differentially regulated genes in experiments comparing two experimental conditions is often a key step in the microarray data analysis process. Many different approaches and methodological developments have been put forward, yet the question remains open. Results: Varmixt is a powerful and efficient novel methodology for this task. It is based on a flexible and realistic variance modelling strategy. It compares favourably with other popular techniques (standard t-test, SAM and Cyber-T). The relevance of the approach is demonstrated with real-world and simulated datasets. The analysis strategy was successfully applied to both a 'two-colour' cDNA microarray and an Affymetrix Genechip. Strong control of false positive and false negative rates is proven in large simulation studies.

Dates et versions

hal-00126119 , version 1 (23-01-2007)

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Citer

P. Delmar, S. Robin, Jj Daudin. VarMixt: efficient variance modelling for the differential analysis of replicated gene expression data. Bioinformatics, 2005, 21 (4) (4), pp.502-508. ⟨10.1093/bioinformatics/bti023⟩. ⟨hal-00126119⟩
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