(2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Organometallic Chemistry Année : 2006

(2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity

Résumé

The antileukemic activity of a series of (2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives was tested on K562 and U937 human leukemia cell lines. Their systemic toxicity was estimated by the corresponding LD50 on mice. The cytotoxic activity of each derivative was significantly better than that of arsenic trioxide and the therapeutic index (T.I. = LD50/IC50) was improved. No correlation between log P and the activity or the toxicity was found.

Dates et versions

hal-00125073 , version 1 (17-01-2007)

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Stéphane Gibaud, Raphaël Alfonsi, Pierre Mutzenhardt, Isabelle Fries, Alain Astier. (2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity. Journal of Organometallic Chemistry, 2006, 691, pp.1081-1084. ⟨10.1016/j.jorganchem.2005.11.007⟩. ⟨hal-00125073⟩
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