A short history of LIM domains (1993-2002): from protein interaction to degradation. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular Neurobiology Année : 2002

A short history of LIM domains (1993-2002): from protein interaction to degradation.

Résumé

The LIM domain is a cysteine-rich zinc-finger motif found in a large family of proteins. In LIM-homeodomain (LIM-hd) transcription factors and LIM-only (LMO) factors, the LIM domains are responsible for key interactions with co-activators, co-repressors, competitors, and other transcription factors, and are therefore of considerable importance for the regulation of associated transcriptional activity. In this review, the authors describe the progressive discoveries of NLI/Ldb/CLIM, LMO and RLIM, and discuss how the field was very recently updated by the finding that LIM-hd transcriptional activity is controlled by regulated degradation of cofactors and LIM-hd themselves.
Fichier non déposé

Dates et versions

hal-00122204 , version 1 (28-12-2006)

Identifiants

  • HAL Id : hal-00122204 , version 1
  • PUBMED : 12428760

Citer

Sylvie Rétaux, Isabelle Bachy. A short history of LIM domains (1993-2002): from protein interaction to degradation.. Molecular Neurobiology, 2002, 26 (2-3), pp.269-81. ⟨hal-00122204⟩

Collections

CNRS
18 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More