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            <title xml:lang="en">Total body water measurement by a modification of the bioimpedance spectroscopy method</title>
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                <title xml:lang="en">Total body water measurement by a modification of the bioimpedance spectroscopy method</title>
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                <term xml:lang="en">Multifrequency bioimpedance</term>
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                <term xml:lang="en">Hemodialysis</term>
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              <p>We propose a method for calculating directly total body water (TBW) volumes (V t) from whole body resistance extrapolated at infinite frequency (R ∞) using a XITRON 4200 impedance meter. Mean TBW resistivities for men and women were determined from measurements of R ∞ and fat-free mass (FFMd) measured by DXA in 58 healthy subjects assuming an average hydration coefficient of 73.2%. Mean differences between V t measured by our new method and those deduced from DXA data were +0.11 ± 1.61 L for women and +0.13 ± 2.16 L for men. For validation, this method was tested with the same resistivities against a 2nd group of 16 volunteers and the mean difference between V t from impedance and DXA was  −0.80 ± 1.43 L. Since the resistance at 50 kHz (R 50) was found to be equal, in average, to 1.230 R ∞ for men and 1.223 R ∞ for women, this method can also be applied at 50 kHz with a similar accuracy by estimating R ∞ from R 50. When our new method was applied to the monitoring of water loss during 28 dialysis runs performed on 13 patients, it predicted a mean water loss equal to 94% of ultrafiltered volume.</p>
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