Global trends of whole genome duplications revealed by the genome sequence of the ciliate Paramecium tetraurelia - Archive ouverte HAL Access content directly
Journal Articles Nature Year : 2006

Global trends of whole genome duplications revealed by the genome sequence of the ciliate Paramecium tetraurelia

Jean-Marc Aury
Olivier Jaillon
* Laurent Duret
Benjamin Noel
Claire Jubin
  • Function : Author
Betina M. Porcel
Béatrice Ségurens
  • Function : Author
Vincent Daubin
Véronique Anthouard
  • Function : Author
Nathalie Aiach
  • Function : Author
Olivier Arnaiz
Alain Billaut
  • Function : Author
Janine Beisson
  • Function : Author
Isabelle Blanc
Francisco Câmara
  • Function : Author
Roderic Guigo
  • Function : Author
Delphine Gogendeau
  • Function : Author
Michael Katinka
  • Function : Author
Anne-Marie Keller
  • Function : Author
Roland Kissmehl
  • Function : Author
  • PersonId : 834786
Catherine Klotz
  • Function : Author
France Koll
  • Function : Author
Jacek K. Nowak
  • Function : Author
Helmut Plattner
  • Function : Author
Julie Poulain
Françoise Ruiz
  • Function : Author
Marek Zagulski
  • Function : Author
Philippe Dessen
Jean Weissenbach
  • Function : Author
  • PersonId : 911249
Claude Scarpelli
Vincent Schächter
  • Function : Author
  • PersonId : 855684
Linda Sperlin
  • Function : Author
Eric Meyer
Jean Cohen
  • Function : Author
  • PersonId : 838156

Abstract

The duplication of entire genomes has long been recognized as having great potential for evolutionary novelties, but the mechanisms underlying their resolution through gene loss are poorly understood. Here we show that in the unicellular eukaryote Paramecium tetraurelia, a ciliate, most of the nearly 40,000 genes arose through at least three successive whole-genome duplications. Phylogenetic analysis indicates that the most recent duplication coincides with an explosion of speciation events that gave rise to the P. aurelia complex of 15 sibling species. We observed that gene loss occurs over a long timescale, not as an initial massive event. Genes from the same metabolic pathway or protein complex have common patterns of gene loss, and highly expressed genes are over-retained after all duplications. The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints.

Dates and versions

hal-00090904 , version 1 (04-09-2006)

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Jean-Marc Aury, Olivier Jaillon, * Laurent Duret, Benjamin Noel, Claire Jubin, et al.. Global trends of whole genome duplications revealed by the genome sequence of the ciliate Paramecium tetraurelia. Nature, 2006, 444 (7116), pp.171-178. ⟨10.1038/nature05230⟩. ⟨hal-00090904⟩
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