Article Dans Une Revue Journal of Natural Products Année : 2005

Pseudoguanolide sesquiterpene lactones from Veroniopsis caudata and their in vitro antiplasmodial activities.

V. Ramanandraibe
  • Fonction : Auteur
M.-T. Martin
  • Fonction : Auteur
D.L. Rakotondramanana
  • Fonction : Auteur
D. Ramanitrahasimbola
  • Fonction : Auteur
M. Mabaïed
  • Fonction : Auteur
P. Rasoanoivo
  • Fonction : Auteur
P. Grellier

Résumé

Two new helenanolide sesquiterpene lactones, 1 and 2, as well as one known related structure, 11α,13-dihydrohelenalin-[2-(1-hydroxyethyl)acrylate] (3), together with 4′-β-D-O-glucopyranosyl-luteolin and ethyl 2,5-dihydroxycinnamate were isolated from an ethyl acetate extract of leaves of Vernoniopsis caudata with potent antiplasmodial activity (IC50 1.6 μg/mL) in a preliminary biological screen. The structures of the new compounds were determined by spectroscopic techniques. The three sesquiterpene lactones 1-3 displayed strong in vitro antiplasmodial activity, with IC 50 values of 1, 0.19, and 0.41 μM, respectively. However, these compounds also exhibited considerable cytotoxicity on KB cells (IC50 < 1 μM in each case). © 2005 American Chemical Society and American Society of Pharmacognosy.

Dates et versions

hal-00086261 , version 1 (18-07-2006)

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Citer

V. Ramanandraibe, M.-T. Martin, D.L. Rakotondramanana, L. Mambu, D. Ramanitrahasimbola, et al.. Pseudoguanolide sesquiterpene lactones from Veroniopsis caudata and their in vitro antiplasmodial activities.. Journal of Natural Products, 2005, 68, pp.800-803. ⟨10.1021/np0401866⟩. ⟨hal-00086261⟩

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