The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Genes to cells : devoted to molecular & cellular mechanisms. Année : 2006

The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila.

Résumé

Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-regulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila.

Dates et versions

hal-00067901 , version 1 (09-05-2006)

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Citer

Sylvain Brun, Sheila Vidal, Paul Spellman, Kuniaki Takahashi, Hervé Tricoire, et al.. The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila.. Genes to cells : devoted to molecular & cellular mechanisms., 2006, 11, pp.397-408. ⟨10.1111/j.1365-2443.2006.00953.x⟩. ⟨hal-00067901⟩
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